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FAGONIA CRETICA / DHANVYAAS

- A Description of the Whole Plant

We shall like to specify with all that Fagonia cretica and Fagonia arabica are two entirely different plants when it comes to the role of plant in healing of Breast Cancer. Scientists have done their bit of research on the Leaf and flower of cretica species so all those patients should use the Tea manufactured from it only.The plant has a lot of thorns attached and one has to be very careful while plucking the leaves and the flowers. It was seen in the Folk areas of India and Pakistan that the "kada" is being used since past 40 odd years to treat the women suffering from Breast Cancer and now after the confirmation in lab reports regarding the potency of herb, every pharma company is making huge efforts to manufacture some kind of tablet / pill which can be taken as a CURE. But still the chemical constituent responsible for the killing of cancerous cells has not been ascertained. We are hereby listing the chemical constituents which are found inside this wonder herb and which are making huge news in the success story of patients.

Main Chemical Constituents found inside this herb which helps in healing of Cancerous Cells are - Ceryl alcohol, Chinovic acid, Harmine, Alanine, Arginine, Glycine, Isoleucine, Leucine, Lysine, Phenylalanine,Oleanolic acid, Campesterol, Stigmasterol

The Plant is found in the arid areas of India and pakistan and in the folk women of these asian countires, its been widely used as a home remedy with a fair degree of success.


Dhanvyaas consists of dried whole plant of Fagonia cretica Linn. syn. F. arabica Linn., F. bruguieri DC. (Fam. Zygophyllaceae), a small spiny under shrub with stiff, more or less prostrate branches found in north-west India and Deccan.

 » SYNONYMS

Sanskrit : Durlabha, Duralabha, Samudranta, Gandhari, Dusparsha, Kachura, Ananta, Dhamasa, Dhamaso, Dhamah, Damah, Tulagnari, Gilaregati, Khorasan
Assamese : Bengali : Duralabha
English : Khorasan thorn, Virgin's Mantle, Virgon's Mantlem
Gujrati : Dhamaaso
Hindi : Damahan, Dhamaasa, Hinguaa, Dhanhare, Dhanvyaas, Dhanvyas, Dramah
Malayalam : Kodittuva
Marathi : Dhamaasaa
Punjabi : Dama, Dhamah, Dhamaha
Tamil : Tulganari
Telugu : Chittigava, Gilaregati

 » DESCRIPTION

a)
Macroscopic

Root -
Tap root externally brownish green, rough, with longitudinal striations, core yellowish-green; fracture, fibrous.

Stem
- Stem pieces 0.5 to 1.5 cm thick, of variable lengths; young green, mature brown; spiny, two pairs of spines present at each node, spines sharp, slender, 1.5 to 2 cm in length; external surface of stem green, whitish brown when dry, striated; transversely smoothened surface showing a thin bark and prominent wood, bark peeling from stem; fracture, short.

Leaf
- Small, subsessile, linear, oblong, leaflets entire, green or blackish brown, 0.5 to 1.5 cm in length and 0.05 to 0.1 cm in width, without any prominent midrib region projected above the level of lamina.

Flower
- Flowers small, pale rose or purple, pedicels slender, 6 to 12 mm long; sepals 3 to 4 mm long, ovate, aristate; petals twice as long as the sepals, spathulate, claw long; ovary hairy, style tapering.

Fruit - Pentagonous schizocarp, composed of five compressed, two valved cocci.

b) Microscopic

Root - T.S. shows outermost cork represented by 4 or 5 layers of small, narrow, tangentially elongated cells; phelloderm composed of 6 to 10 layers of somewhat
tangentially elongated, thin walled parenchymatous cells, some cells having rhom boid crystals of calcium oxalate measuring 10 to 15 μ in length and 8 to 10 μ in width; outer part of secondary phloem characterised by the presence of abundant, but small patches of 2 or 3 thick walled phloem fibres; wood composed of vessels, xylem fibres and traversed by 1 to 3 seriate medullary rays; vessels arranged in singles or doubles; fibres long, thick walled with tapering ends and measuring upto 500 μ in length and about 25 μ in width.

Stem - T.S. shows more or less circular outline; single layered epidermis with thick cuticle; unicellular trichomes occasionally present; cortex consisting of 7 to 10 layers of parenchymatous cells showing large patches of fibres; sclereids with narrow lumen occurring singly or in groups in the cortex, measuring upto 50 μ in diam.; several cortical cells contain tannins; secondary phloem consisting of thin walled cells; vascular cambium composed of 3 to 4 layers of thin walled tangentially elongated cells; secondary xylem composed of fibres, tracheids, vessels, xylem parenchyma; fibres long, thick walled with tapering ends and measuring 260 to 950 μ in length and upto 20 μ in width; medullary rays mostly uniseriate or sometimes biseriate; pith composed of large thin walled parenchymatous cells, some cells containing tannins; rhomboid crystals measuring 18 to 30 μ in length and 12 to 20 μ in width present in cortex and pith.

Leaf - Isobilateral; single layered epidermis consisting of mostly tangentially elongated cells covered with thick cuticle. In surface view both upper and lower epidermii show anomocytic type of stomata, epidermal cells polygonal in shape; 2 or 3 layered palisade cells present on both the sides, adjacent to the epidermis; vascular bundles show xylem towards lower side and phloem towards upper side; sclerenchyma tissue occur as a bundle cap just above the phloem; small lateral vascular bundles also present in lamina; vein-islet number 11 to14; stomatal index 16 to 17 on lower epidermis and 5 to 7 on upper epidermis; palisade ratio 2 or 3 on upper epidermis and 2 to 4 on lower epidermis.

Powder Yellowish - white, bitter taste, showing groups of fibres, bordered pitted vessels, fragments of palisade tissue, sclereids, rhomboid crystals of calcium oxalate, cork cells, and unicellular glandular and nonglandular trichomes (both from fruit epicarp), epidermal cells (cubical, rectangular or polygonal) with slightly wavy walls and anomocytic stomata.

 » IDENTITY, PURITY AND STRENGTH

Foreign matter Not more than 2 per cent, Appendix 2.2.2.
Total Ash Not more than 10 per cent, Appendix 2.2.3.
Acid-insoluble ash Not more than 0.4 per cent, Appendix 2.2.4.
Alcohol-soluble extractive Not less than 5 per cent, Appendix 2.2.6.
Water-soluble extractive Not less than 10 per cent, Appendix 2.2.7.

 » T.L.C.

T.L.C. of the alcoholic extract on silica gel 'G' plates (0.2 mm thick) using chloroform : methanol: acetic acid (70:30:0.2) shows under UV (254 nm) four spots at Rf. 0.14, 0.32, 0.46 (all violet) and 0.72 (yellowish green). Under UV (366nm) six fluorescent spots appear at Rf. 0.14, 0.32 (both brown), 0.39, 0.51, 0.61 and 0.72 (all pink). On exposure to iodine vapour nine spots appear at Rf. 0.14, 0.19, 0.28, 0.35 (all yellow), 0.46 (faint orange), 0.51, 0.61 and 0.72 (all yellow). On spraying with vanillin sulphuric acid reagent and heating the plate at 110oC for 10 min. ten spots appear at Rf. 0.06 (bluish grey), 0.14 (violet), 0.19 (brown), 0.28 (violet), 0.35 (brown), 0.39 (violet), 0.46 (brown), 0.51 (violet), 0.61 (brown) and 0.72 (violet).

 » CONSTITUENTS

Alkaloids (Harmine); amino acids (alanine, glycine, leucine, arginine isoleucine, lysine, phenylalanine, proline, tyrosine and valline); terpenoids of oleanane group.

 » PROPERTIES AND ACTION

Rasa : Madhura, Katu, Tikta, Kashay
Guna : Laghu, Snigdha
Virya : Ushan
Vipaka : Madhura
Karma : Kaphahara, Medohara, Pittahara, V¡tahara

 » IMPORTANT FORMULATIONS

Kantkaryavaleha, Maha Vishgarbha Taila, Mahatiktaka Ghrita, Panchamrita kvath Churna, Patoladi ghrita, Rasnadi kvath Churna, Sudrshan Churna, Ushirasava

 » THERAPEUTIC USES

D¡ha, Graha¸¢, Gulma, Jvara, K¡sa, KuÀ¶ha, Prameha, Raktapitta, V¡tarakta, Visarpa, Atis¡ra, ViÀamajvara, T¤À¸¡, Moh